Aromatization is the conversion of testosterone to estradiol (estrogen), or androstenedione to estrone. Occurs as a natural way in the process of metabolism – and when using drugs prone to aromatization.
The causes of aromatization
I will not talk about natural transformations, but let's talk about provoked steroids. The reasons can be three:
The first is the use of excess dosage for a particular user of flavoring steroids. To begin acquaintance with dangerous steroids it is necessary from the minimal dosages and not to increase them until they cease to render the proper effect. If these steroids are taken more than two months without interruption – aromatase inhibitors become necessary.
The second reason is an unhealthy liver. If you do everything right, and estrogenic side effects do not care – go check the liver.
Third , it is an elevated level of the aromatase enzyme in the body, or a large number of estrogen receptors in the skin, fatty layer and breast glands. This case is special, and you can avoid troubles here only in one way – to give up flavoring steroids once and for all.
Antiestrogens are necessary elements to ensure an absolutely safe course of the course. Conscious athletes, both beginners and those who have experience or are professionals, are responsible for the state of their body. The use of steroids can lead to a certain type of risk to your health: the manifestation of gynecomastia, infertility, impaired liver function … We consider it our duty to help your health condition and you recommend getting all the recommended precautions to achieve your medications with confidence. All the necessary protective measures available in our “Anti-estrogens”.
Antiestrogens are modulators of estrogen receptors. These drugs block estrogen receptors, but do not reduce the level of estrogens in the blood. Estrogens reduce only aromatase inhibitors.
To group of the given preparations to concern:
- Clomiphene citrate
- Tamoxifen (tamoxifen citrate)
- Toremifene citrate
- Differences of Clomifene Tamoxifen and Toremifene.
Clomiphene works more selectively on the pituitary gland than tamoxifen and toremifene. Tamoxifen and Toremifene block estrogen receptors not only in the pituitary and hypothalamus, but throughout the body. Toremifene is a more modern version of tamoxifen, where some side effects have been removed, thus the drug is more preferable.
Disadvantages of tamoxifen, relative to clomiphene:
- Decreased libido and quality of erection.
- Increases the amount of SHBG in the blood.
- More negatively she looks at the sight.
- More toxic to the body.
- Increases the number of progesterone receptors.
Disadvantages of clomiphene, relative to tamoxifen
Price, the drug is more expensive
Does not block estrogen receptors on the mammary glands, thus it is useless in the treatment of gynecomastia.
Clomiphene citrate is a more preferred drug for post-course therapy, and for increasing testosterone levels, since the drug has fewer side effects, while working selectively, and better restores testosterone secretion. Also, tamoxifen can not be used after taking 19-nor drugs, such as: Nandrolone and Trenbolone.
Tamoxifen citrate should be used as a second pereparit on post-course therapy, when recovering from very long courses or when recovering from “heavy” courses of anabolic steroids. Separately, the drug can be used as the main drug for gynecomastia, aromatase inhibitors can serve as auxiliary agents.
Toremifene can be used both on post-course therapy, but clomiphene is more preferable, and for the treatment of gynecomastia. In this case, toremifene is preferable to tamoxifen, since it has fewer side effects.
Nonsteroidal antiestrogens and their effects
Since the rejection of steroids is by far not the most logical and correct decision, we will consider the second method, namely the use of special pharmacological products that will help to reduce the level of activity of female hormones in the male body.
These substances are called antiestrogens, in addition to the ability to fight the female hormone, they can also increase the level of synthesized natural testosterone. All these drugs can be divided into several groups according to their characteristics: steroid anti-aromatics, non-steroidal anti-aromatics, non-steroidal estrogen receptor blockers, others, incl. natural, anti-estrogenic remedies.
Developed antiestrogens were only recently, in 1980. At the beginning of their history, they were used exclusively in medicine, in the treatment of cancer in women. And today, non-steroidal estrogen antagonists are used by bodybuilders to treat problems associated with gynecomastia. In the market of variations of drugs that athletes can use, a great many. There are both plant anti-estrogens , and synthetic versions that can overcome gynecomastia. However, we will not list them all, but only describe the most effective and popular ones.
It should be noted that with the use of easily aromatizing steroids, the best effect will be provided by the joint application of preparations of the second group. For example, daily intake of 10-30 mg of nolvadex and 25-50 mg of proviron almost completely protects the body from unwanted clusters of estrogens. However, we want to warn: to dosages of antiestrogens should be approached very carefully, as well as to the dosages of any other drugs. Remember that some amount of estrogen is required for the body to work properly. And complete blocking of estrogen can lead to side effects such as decreased libido, depression and mood worsening. So, try to observe the measure in everything.
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